Intracellular Potassium Concentration During Ammonia Intoxication

Liver disease and ammonia intoxication.

The relation between ammonia intoxication and liver disease is not clear. Ammonia appears to be relatively non-toxic to normal individuals, whereas some patients with liver disease appear to be exquisitely sensitive to dietary protein, ammonia-releasing substances, and ammonium salts. In an attempt to elucidate this relationship the intravenous LD(50) of ammonium chloride was determined in both...

Ammonia Intoxication in Hepatic Coma

Blood ammonia nitrogen was determined in 36 cases of hepatic coma and 63 cases of liver disease. Significant elevations (PL 0.001) were noted in coma due to hepatitis and cirrhosis and the mortality rate was 89% and 9 1.3% respectively. Raised ammonia nitrogen in hepatic coma is a sign of grave prognosis (JPMA 34 : 9, 1984).

Intracellular potassium (K+) concentration decrease is not obligatory for apoptosis

Potassium Canrenoate and Digitalis Intoxication

Reference 1 is to Campbell's Letter to the Editor and reference 2 is to Pettinger et al., Am J Physiol 225: 234238, 1973. *P < 0.025 compared with value in 3-week-old spontaneously hypertensive rats. nous substrate and did not demonstrate that substrate remained in excess during that entire period, and (2) they did not use angiotensinase inhibitors during incubation. Incidentally, De Jong et al...

Ammonia intoxication in portal systemic encephalopathy.

Portal systemic encephalopathy (PSE) comprises of five major features, of which ammonia intoxication of the central nervous system is the only specific feature. Ammonia is a key intermediate in the metabolism of nitrogen. Oxidative deamination of aminoacids is one of the major ammonia producing pathways. It occurs predominantly in the liver, to a lesser extent kidneys and also in the brain. The...